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Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease

Identifieur interne : 000B03 ( Main/Corpus ); précédent : 000B02; suivant : 000B04

Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease

Auteurs : Maaike Bakker ; Rianne A. J. Esselink ; Marten Munneke ; Patricia Limousin-Dowsey ; Hans D. Speelman ; Bastiaan R. Bloem

Source :

RBID : ISTEX:776702D0CB703C11D06ADDFFD5225C9997D08A4B

English descriptors

Abstract

Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta‐analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase. © 2004 Movement Disorder Society

Url:
DOI: 10.1002/mds.20116

Links to Exploration step

ISTEX:776702D0CB703C11D06ADDFFD5225C9997D08A4B

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<p>Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta‐analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase. © 2004 Movement Disorder Society</p>
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<title>Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease</title>
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<abstract lang="en">Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta‐analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase. © 2004 Movement Disorder Society</abstract>
<note type="funding">Prinses Beatrix Fonds</note>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
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<date>2004</date>
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<number>19</number>
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